Large-Scale Genome-Wide Association Studies Consortia
نویسندگان
چکیده
منابع مشابه
Large-scale genome-wide association studies consortia: blessing, burden, or necessity?
In the current issue of Circulation: Cardiovascular Genetics, Preuss and colleagues1 describe the design of the Coronary ARtery DIsease Genome-wide Replication And Meta-Analysis (CARDIoGRAM) consortium. CARDIoGRAM is one of several consortia that have formed in the past few years in order to combine data from different genome-wide association studies (GWAS) in large-scale metaanalyses. Many of ...
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متن کاملGenome-wide Association Studies
Progress in probabilistic generative models has accelerated, developing richer models with neural architectures, implicit densities, and with scalable algorithms for their Bayesian inference. However, there has been limited progress in models that capture causal relationships, for example, how individual genetic factors cause major human diseases. In this work, we focus on two challenges in par...
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Genome-wide association (GWA) studies are best understood as an extension of candidate gene association studies, scaled up to cover hundreds of thousands of markers across the genome in samples usually of several thousand cases and controls. The GWA approach allows the detection of much smaller effect sizes than with previous linkage-based genome-wide studies. However, this sensitivity makes th...
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Scientific research has shifted from studies conducted by single investigators to the creation of large consortia. Genetic epidemiologists, for example, now collaborate extensively for genome-wide association studies (GWAS). The effect has been a stream of confirmed disease-gene associations. However, effects on human subjects oversight, data-sharing, publication and authorship practices, resea...
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ژورنال
عنوان ژورنال: Circulation: Cardiovascular Genetics
سال: 2010
ISSN: 1942-325X,1942-3268
DOI: 10.1161/circgenetics.110.958397